Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

668
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
668

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of percutaneous and transarterial fiducial marker placement before proton therapy for pancreatic cancer.

Journal of radiation research·2026
Same author

Association of Underweight, Sarcopenia, and Cancer Cachexia with Survival Outcomes in Hypopharyngeal Cancer Radiotherapy.

Cancers·2026
Same author

Impact of intensity-modulated radiotherapy on survival and pulmonary toxicities for localized esophageal squamous cell carcinoma.

Japanese journal of clinical oncology·2026
Same author

A unique microglia subset associated with aggressive α-synucleinopathy uncovered in a rapidly progressive multiple system atrophy cerebellar type model.

Neurobiology of disease·2025
Same author

Facilitated α-synuclein oligomer sharing among glial cells by a centrally acting connexin inhibitor attenuates a rapidly progressive multiple system atrophy-cerebellar type model by reducing the neuronal α-synuclein burden.

Acta neuropathologica communications·2025
Same author

Blood exosome connexins and small RNAs related to demyelinating disease activity.

Annals of clinical and translational neurology·2025

Related Experiment Video

Updated: Feb 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.4K

Structural changes in Parkinson's disease: voxel-based morphometry and diffusion tensor imaging analyses based on

Kazufumi Kikuchi1, Akio Hiwatashi2, Osamu Togao1

  • 1Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

European Radiology
|July 6, 2017
PubMed
Summary

Parkinson's disease patients with sympathetic dysfunction show brain structure changes. Advanced MRI techniques like VBM and DTI correlate with 123I-metaiodobenzylguanidine (MIBG) uptake, indicating potential for detecting brain damage.

Keywords:
Diffusion tensor imagingMagnetic resonance imagingNeurodegenerative diseasesParkinson’s diseaseRadionuclide imaging

More Related Videos

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.3K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K

Related Experiment Videos

Last Updated: Feb 27, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.4K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.3K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.4K

Area of Science:

  • Neuroimaging
  • Neurology
  • Cardiology

Background:

  • Parkinson's disease (PD) is associated with sympathetic nervous system dysfunction.
  • 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy can quantify cardiac sympathetic denervation in PD.
  • The relationship between cardiac sympathetic function and brain microstructural changes in PD is not fully understood.

Purpose of the Study:

  • To investigate the association between microstructural brain alterations and 123I-MIBG uptake in Parkinson's disease patients.
  • To utilize voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) to analyze brain structure in relation to MIBG scintigraphy results.

Main Methods:

  • Retrospective analysis of 24 Parkinson's disease patients undergoing 3T MRI and 123I-MIBG scintigraphy.
  • Patients categorized into MIBG-positive (n=12) and MIBG-negative (n=12) groups based on heart/mediastinum (H/M) ratio.
  • VBM and DTI applied to detect structural and white matter integrity differences between the two groups.

Main Results:

  • Lower H/M ratio correlated with significantly reduced gray matter volume in the right inferior frontal gyrus (p<0.0001).
  • Patients with low H/M ratios showed significantly reduced fractional anisotropy in several white matter tracts, including the left anterior thalamic radiation and left uncinate fasciculus (p<0.05).
  • These findings suggest a link between cardiac sympathetic denervation and specific brain structural changes in PD.

Conclusions:

  • Voxel-based morphometry and diffusion tensor imaging can identify microstructural brain changes in Parkinson's disease.
  • These advanced MRI techniques correlate with the degree of 123I-MIBG uptake, reflecting sympathetic dysfunction.
  • Advanced MRI methods offer precise detection of gray and white matter damage associated with PD progression.