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Cough Hypersensitivity Syndrome: A Few More Steps Forward.

Woo Jung Song1, Alyn H Morice2

  • 1Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Allergy, Asthma & Immunology Research
|July 6, 2017
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Summary

Chronic cough may stem from a hypersensitive cough reflex, a condition termed cough hypersensitivity syndrome. New P2X3 receptor antagonists offer a promising therapeutic strategy for intractable cough.

Keywords:
Coughhypersensitivitypathophysiology

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Area of Science:

  • Neuroscience
  • Pulmonology
  • Pharmacology

Background:

  • The cough reflex is essential for airway protection but can become hypersensitive, leading to chronic cough.
  • Chronic cough is a significant health issue associated with high morbidity.
  • A unifying concept of cough hypersensitivity syndrome proposes aberrant neurophysiology as a common cause.

Purpose of the Study:

  • To review the paradigm shift towards understanding chronic cough as a hypersensitivity syndrome.
  • To highlight recent therapeutic advances and mechanistic insights into cough.
  • To discuss the role of validated cough measurement tools.

Main Methods:

  • Review of recent scientific literature on cough reflex, hypersensitivity, and therapeutics.
  • Analysis of emerging evidence on the neurophysiology of chronic cough.
  • Evaluation of data from randomized clinical trials of P2X3 receptor antagonists.

Main Results:

  • Emerging evidence supports aberrant neurophysiology as the etiology of cough hypersensitivity syndrome.
  • P2X3 receptor antagonists represent a significant therapeutic advance for intractable cough.
  • Validated cough measurement tools are available for clinical assessment.

Conclusions:

  • Cough hypersensitivity syndrome offers a new framework for understanding and treating chronic cough.
  • P2X3 receptor antagonists provide a targeted treatment and research tool.
  • Continued research into cough mechanisms promises future therapeutic developments.