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Targeted radionuclide therapy in combined-modality regimens.

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Targeted radionuclide therapy (TRT) uses targeted radioactive agents to treat cancer. Its increasing use in bone, neuroendocrine, and liver tumors highlights the need for integration into broader cancer treatment strategies.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Targeted radionuclide therapy (TRT) employs radioisotopes and targeted molecules for cancer treatment.
  • TRT combines molecular targeting specificity with the cytotoxic effects of ionizing radiation.
  • Available targeting vectors include antibodies, peptides, and small molecules, enabling tailored treatment approaches.

Purpose of the Study:

  • To review the current state and future prospects of targeted radionuclide therapy.
  • To evaluate the integration of TRT into multimodality cancer treatment protocols.
  • To discuss the expanding applications of TRT in clinical practice.

Main Methods:

  • Review of current literature on targeted radionuclide therapy.
  • Analysis of clinical applications and ongoing developments in TRT.
  • Evaluation of vector-radionuclide pairings and their tumor-specific characteristics.

Main Results:

  • TRT utilizes diverse targeting vectors and radioisotopes for personalized cancer treatment.
  • Successful adoption of radium-223 dichloride and ongoing development of 177Lu-DOTATATE and 90Y-microspheres.
  • TRT offers dual therapeutic and diagnostic applications in select cases.

Conclusions:

  • The expanding use of TRT necessitates strategic integration into multimodality cancer care.
  • TRT shows significant promise for treating various cancers, including bone metastases, neuroendocrine tumors, and hepatic tumors.
  • Future research should focus on optimizing TRT delivery and combination therapies.