Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pinching-off of Coated Vesicles01:32

Pinching-off of Coated Vesicles

4.3K
Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
4.3K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

3.6K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
3.6K
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

6.9K
In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
6.9K
Curvilinear Motion: Normal and Tangential Components01:27

Curvilinear Motion: Normal and Tangential Components

1.0K
When a car traverses a curved road, its motion can be elucidated by breaking it down into tangential and normal components. The car-centric coordinates attached to the vehicle move with it.
The positive direction of the t-axis aligns with the increasing position of the car along the curved path, denoted by the unit vector ut. Simultaneously, the n-axis, perpendicular to the t-axis, dissects the curved path into differential arc segments, each forming the arc of a circle with a radius of...
1.0K
Surface Tension of Fluid01:22

Surface Tension of Fluid

1.8K
Surface tension is a fundamental property of fluids, occurring at the boundary between a liquid and a gas or between two immiscible liquids. This phenomenon arises from the cohesive forces between molecules at the fluid's surface, creating an effect similar to a stretched elastic membrane. Inside each fluid, molecules are equally attracted in all directions by neighboring molecules, but surface molecules experience a net inward force, resulting in surface tension.
Surface tension varies...
1.8K
Viscosity of Fluid01:19

Viscosity of Fluid

1.5K
Viscosity measures the resistance a fluid offers to flow and deformation. It results from internal friction between layers of fluid moving relative to one another. Dynamic viscosity, denoted by the Greek letter mu (μ), quantifies the force needed to move one fluid layer over another. For Newtonian fluids like water and air, the relationship between the shearing stress and the rate of shearing strain is linear, meaning their viscosity remains constant regardless of the applied stress.
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Building bundles by the numbers.

eLife·2026
Same author

Cracking donuts and sorting lipids: Geometry controls archaeal membrane stability and lipid organization.

The Journal of chemical physics·2026
Same author

Supramolecular Assembly of Collagen-Mimetic Peptide D-Periodic Fibrils and Nanoassemblies.

Biomacromolecules·2026
Same author

Structural defects in amyloid-β fibrils drive secondary nucleation.

Nature communications·2026
Same author

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Balancing stability and flexibility when reshaping archaeal membranes.

eLife·2025

Related Experiment Video

Updated: Feb 27, 2026

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
06:26

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles

Published on: December 7, 2017

11.6K

Curvature variation controls particle aggregation on fluid vesicles.

Afshin Vahid1, Anđela Šarić2, Timon Idema1

  • 1Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands. a.vahidbelarghou@tudelft.nl t.idema@tudelft.nl.

Soft Matter
|July 6, 2017
PubMed
Summary

Particles on curved membranes attract and self-organize. This physical interaction can drive cellular processes like cell division and guide macromolecule organization on cellular membranes.

More Related Videos

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.7K
Three-dimensional Particle Tracking Velocimetry for Turbulence Applications: Case of a Jet Flow
13:02

Three-dimensional Particle Tracking Velocimetry for Turbulence Applications: Case of a Jet Flow

Published on: February 27, 2016

13.1K

Related Experiment Videos

Last Updated: Feb 27, 2026

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles
06:26

Pulling Membrane Nanotubes from Giant Unilamellar Vesicles

Published on: December 7, 2017

11.6K
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.7K
Three-dimensional Particle Tracking Velocimetry for Turbulence Applications: Case of a Jet Flow
13:02

Three-dimensional Particle Tracking Velocimetry for Turbulence Applications: Case of a Jet Flow

Published on: February 27, 2016

13.1K

Area of Science:

  • Biophysics
  • Cell Biology
  • Soft Matter Physics

Background:

  • Cellular membranes dynamically change shape, crucial for biological functions.
  • Membrane shape and protein interactions are interdependent, influencing cellular processes.
  • Understanding these interactions on curved membranes is key to cellular mechanics.

Purpose of the Study:

  • To investigate membrane-mediated interactions between particles on closed, anisotropically curved membranes.
  • To model these interactions using colloids adhered to ellipsoidal membrane vesicles.
  • To explore the potential applications in cellular processes and artificial vesicle manipulation.

Main Methods:

  • Utilizing ellipsoidal membrane vesicles with adhered colloids as a model system.
  • Observing particle behavior and self-organization on curved membrane surfaces.
  • Analyzing the relationship between particle arrangements and vesicle shape.

Main Results:

  • Particles on closed systems exhibit mutual attraction.
  • Particles align with the direction of greatest membrane curvature.
  • Multiple particles form arcs or rings, leading to 'snowman' vesicle shapes.

Conclusions:

  • Anisotropic membrane curvature drives particle self-organization.
  • These physical interactions can be harnessed by cells for macromolecule localization and initiating cell division.
  • The principle can be applied to engineering artificial vesicle division.