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Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

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Prenatally Diagnosed Infant AML.

Mary-Pat Schlosser¹, Shannon Bucking², Brigitte Lemyre³

¹Division of Hematology/Oncology.

Journal of Pediatric Hematology/Oncology

|July 6, 2017

Summary

This is the first reported case of a fetus diagnosed with acute myeloid leukemia in utero. The infant was diagnosed with monocytic acute myeloid leukemia but sadly passed away shortly after emergency delivery.

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Area of Science:

Perinatology
Pediatric Hematology
Medical Genetics

Background:

Prenatal diagnosis of fetal hematologic malignancies is rare.
Acute myeloid leukemia (AML) is a significant concern in pediatric oncology.

Observation:

A fetus was diagnosed with acute myeloid leukemia, monocytic type, in utero via cordocentesis.
The diagnosis was made during an investigation for fetal hepatomegaly.

Findings:

Cytogenetic analysis revealed mixed lineage leukemia (MLL) duplication without gene disruption or trisomy.
The fetus had AML without concurrent Down syndrome.

Implications:

This case highlights the possibility of in utero diagnosis of fetal AML.
There is a critical need for established management guidelines for fetal hematologic malignancies.