Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The DNA Helix

The DNA Helix

DNA Packaging

DNA Packaging

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and safety of short-course radiotherapy versus total neoadjuvant therapy in older rectal cancer patients: a randomised pragmatic trial (SHAPERS).

ESMO gastrointestinal oncology·2026

Same author

TORPP - Turtles, One Health Research & Plastic Pollution: A multidisciplinary consortium to evaluate the environmental and health impact of Micro/NanoPlastics (MNPs) pollution.

One health (Amsterdam, Netherlands)·2024

Same author

Giant eagle syndrome with pseudoarthrosis and peripheral facial palsy.

Revista de neurologia·2023

Same author

Changes in anticancer treatment plans in patients with solid cancer hospitalized with COVID-19: analysis of the nationwide BSMO-COVID registry providing lessons for the future.

ESMO open·2022

Same author

A modular spring-loaded actuator for mechanical activation of membrane proteins.

Nature communications·2022

Same author

High speed atomic force microscopy to investigate the interactions between toxic Aβ<sub>1-42</sub> peptides and model membranes in real time: impact of the membrane composition.

Nanoscale·2019

Same journal

5-Year advances in semisacrificial metal foam-derived materials for energy storage and electrocatalysis.

Nanoscale·2026

Same journal

Application of nanogenerators in oral and respiratory systems: a review.

Nanoscale·2026

Same journal

High-efficiency BCN quantum dots with enhanced carrier kinetics enabled by synergistic control of the atomic ratio and interface engineering.

Nanoscale·2026

Same journal

Fluorescence imaging for liver diseases: probe design strategies and diagnostic applications.

Nanoscale·2026

Same journal

Robust and well-structured graphene oxide membranes crosslinked by phenylboronic acid for efficient heavy metal ion sieving.

Nanoscale·2026

Same journal

Lasing characteristics and stress-tuning effects in GaN beam microcavities.

Nanoscale·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 27, 2026

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

Published on: March 20, 2021

A tensegrity driven DNA nanopore.

O Mendoza¹, P Calmet, I Alves

¹CBMN, UMR5248, 33600 Pessac, France. juan.elezgaray@u-bordeaux.fr.

|July 6, 2017

Summary

This summary is machine-generated.

This study introduces a novel DNA nanopore design for controlled transport. The tensegrity mechanism offers stable electrical signals for precise single-molecule DNA sensing applications.

More Related Videos

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

High-throughput Flow-cytometry Measurement of Cellular Mechanotype Based on Rupture and Delivery of DNA Tension Probes into Cells

High-throughput Flow-cytometry Measurement of Cellular Mechanotype Based on Rupture and Delivery of DNA Tension Probes into Cells

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Feb 27, 2026

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

DNA Tension Probes to Map the Transient Piconewton Receptor Forces by Immune Cells

Published on: March 20, 2021

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

High-throughput Flow-cytometry Measurement of Cellular Mechanotype Based on Rupture and Delivery of DNA Tension Probes into Cells

High-throughput Flow-cytometry Measurement of Cellular Mechanotype Based on Rupture and Delivery of DNA Tension Probes into Cells

Published on: June 13, 2025

Area of Science:

Biotechnology
Nanotechnology
Molecular Biology

Background:

Controlling transport across natural and synthetic membranes is crucial for biotechnology, including sensing and drug delivery.
Previous DNA channels faced challenges with unstable electrical signatures due to steric hindrance for transport regulation.
Existing methods for regulating transport across DNA channels lack stability and precise control.

Purpose of the Study:

To introduce a new DNA nanopore design for precise control over electric channel conductance.
To develop a method for regulating analyte flux in DNA channels using a tensegrity-driven mechanism.
To enable stable and defined electrical signatures for advanced sensing applications.

Main Methods:

Design and fabrication of a novel DNA nanopore utilizing a tensegrity-driven mechanism.
Investigation of ionic transport modulation through the addition of specific DNA sequences.
Characterization of electrical signatures and analyte flux under varying conditions.

Main Results:

The new DNA nanopore design successfully inhibits the flux of small analytes.
Ionic transport is tightly controlled and modulated by specific DNA sequences.
The system exhibits clearly defined current signals without gating, indicating high stability.
This approach overcomes the limitations of previous designs relying on steric hindrance.

Conclusions:

The developed tensegrity-driven DNA nanopore offers a stable and controllable platform for transport regulation.
This innovation opens new perspectives for single-molecule DNA sensing with enhanced precision.
The precise control over ionic transport paves the way for advanced biotechnological applications.