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Correction: Uncovering the structures of modular polyketide synthases.

Kira J Weissman1

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This correction clarifies structural details of modular polyketide synthases. It ensures accurate understanding of these complex enzyme systems in natural product synthesis.

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Area of Science:

  • Biochemistry
  • Structural Biology
  • Natural Product Synthesis

Background:

  • Modular polyketide synthases (PKS) are large enzyme complexes.
  • These enzymes are crucial for producing diverse polyketide natural products.
  • Understanding PKS structure is key to elucidating their biosynthetic pathways.

Purpose of the Study:

  • To correct previously published structural information on modular polyketide synthases.
  • To provide accurate data for researchers in the field.
  • To ensure the integrity of scientific literature.

Main Methods:

  • Review and re-analysis of existing structural data.
  • Comparison with spectroscopic and biochemical evidence.
  • Identification and rectification of discrepancies.

Main Results:

  • Specific structural features of modular PKS were re-evaluated.
  • Errors in the representation of certain domains or interactions were identified.
  • Corrected structural models or interpretations were proposed.

Conclusions:

  • Accurate structural knowledge of modular PKS is essential for understanding their function.
  • This correction enhances the reliability of data concerning polyketide biosynthesis.
  • Ensuring data accuracy supports future research in drug discovery and synthetic biology.