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Updated: Feb 27, 2026
06:53
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
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Mechanical role of a growing solid tumor on cortical folding
Mir Jalil Razavi1, Mary Reeves2, Xianqiao Wang1
1a College of Engineering, University of Georgia , Athens , GA , USA.
Summary
Prenatal solid tumors can disrupt fetal brain development, altering cortical folding. Tumor growth and location significantly impact brain convolution, potentially leading to disorders.
Area of Science:
- Neuroscience
- Developmental Biology
- Biophysics
Background:
- Cortical folding (gyrification) is crucial for mammalian brain function.
- Prenatal solid tumors can interfere with normal brain development.
- Understanding tumor impact on brain structure is vital for predicting developmental disorders.
Purpose of the Study:
- To investigate the effects of growing solid tumors on fetal brain cortical folding.
- To model the developmental mechanism of cortical convolution under tumor influence.
- To analyze how tumor characteristics affect brain structure.
Main Methods:
- Theoretical analysis of deformation and stress in a double-layered brain model.
- Non-linear finite element simulations for crease formation analysis.
- Parametric studies on tumor size, location, and growth speed.
Main Results:
- Tumor size, location, and growth speed significantly influence cortical folding patterns.
- A critical tumor distance from the cortex/core interface maximizes its effect.
- Growing tumors decrease the gyrification index, while stiffness has minimal impact.
Conclusions:
- Growing solid tumors disrupt fetal brain convolution.
- Tumor characteristics critically determine the extent of cortical folding alteration.
- This research provides insights into tumor-induced brain developmental abnormalities.
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