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Cytotoxic gelsedine-type indole alkaloids from Gelsemium elegans

Hai-Tao Wang1, Yan-Chun Yang2, Xia Mao3

  • 1a Department of E.N.T. , Second Hospital of Jilin University , Changchun 130041 , China.

Journal of Asian Natural Products Research
|July 7, 2017
PubMed

Keywords:
Gelsemium elegansLoganiaceaealkaloidscytotoxicity

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
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