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Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis
Rafael Abós-Herràndiz1, Teresa Rodriguez-Blanco2, Isabel Garcia-Allas1
1Catalan Health Institute (ICS), Division of Primary Health Care, Department of Health, Barcelona, Catalonia, Spain.
Background:
The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths.
Methods:
The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes.
Results:
Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively.
Conclusions:
Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.
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