Related Experiment Video
Updated: Feb 27, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Sudden Sensorioneural Hearing Loss and Autoimmune Systemic Diseases
Bruno Almeida Antunes Rossini1, Norma de Oliveira Penido1, Mario Sergio Lei Munhoz1
1Department of ENT, Universidade Federal de São Paulo, São Paulo, Brazil.
Systemic autoimmune diseases (SAD) are relevant in sudden sensorineural hearing loss (SNHL). This study found 3.83% of SNHL patients had SAD, often with severe, unilateral, and profound hearing loss, but showed poor treatment response.
Area of Science:
- Otolaryngology
- Rheumatology
- Immunology
Background:
- Sudden sensorineural hearing loss (SNHL) is linked to systemic autoimmune diseases (SAD).
- Immune-mediated SNHL can be unilateral initially, affecting the other ear later.
- Early treatment offers a chance for reversible SNHL in immune-mediated cases.
Purpose of the Study:
- Describe clinical and audiological findings in patients with idiopathic SNHL and SAD.
- Identify probable immune-mediated SNHL cases.
- Estimate the prevalence of SAD in patients presenting with sudden SNHL.
Main Methods:
- Observational retrospective cohort study.
- Inclusion of patients diagnosed with SAD.
- Literature review of scientific repositories.
Main Results:
- 339 patients with sudden SNHL were evaluated; 13 (3.83%) had SAD.
- Three patients had bilateral involvement (16 ears total).
- Clinical, epidemiological, and audiological data were analyzed.
Conclusions:
- SAD prevalence is significant in sudden SNHL patients.
- Most SAD-associated SNHL cases presented with tinnitus, dizziness, unilateral, and profound hearing loss.
- These patients exhibited more severe initial impairment, higher bilateral involvement, poorer treatment response, and worse prognosis compared to SNHL of unknown etiology.
Related Concept Videos
Autoimmune Disorders
Concept and Mechanism of Autoimmune Diseases
The immune...
Disorders of the Autonomic Nervous System
Raynaud's disease, also known as Raynaud's...
Rheumatic Heart Disease I: Introduction
What is the Immune System?
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hypersensitivity Reactions: Immune-Complex Reactions

