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Candida pararugosa: First Reported Bloodstream Infection in an Adult
Guy El Helou1, Elizabeth Palavecino2
1Infectious Disease, Wake Forest Baptist Medical Center.
Abstract:
Candida pararugosa is a yeast that has been previously isolated in various human specimens. The first reported isolation was from human feces in 1998, with subsequent reports of positive cultures from the oral cavity where it was thought to represent colonization rather than true infection. Though it has been isolated from other human sites, its clinical significance and manifestations are poorly characterized. We report the case of a 39-year-old woman on parenteral hyperalimentation who developed post abdominal surgery sepsis and surgical wound necrotizing fasciitis. Candida pararugosa was isolated from two different blood cultures and the patient's clinical status improved after initiation of therapy with micafungin. Though it was not clear whether sepsis was driven by the candidemia or the necrotizing fasciitis or both, this report appears to be the first case of Candida pararugosa bloodstream infection described in an adult.
Insights
This study reports the first adult case of Candida pararugosa bloodstream infection. The yeast was isolated from a patient with sepsis and necrotizing fasciitis, who improved with antifungal treatment.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Candida pararugosa is a yeast species with limited documented clinical significance.
- Previous isolations from human specimens suggested colonization rather than infection.
Observation:
- A 39-year-old woman developed sepsis and necrotizing fasciitis post-abdominal surgery.
- Candida pararugosa was identified in multiple blood cultures from the patient.
Findings:
- This case represents the first reported instance of Candida pararugosa bloodstream infection in an adult.
- The patient's condition improved following treatment with micafungin, an antifungal medication.
Implications:
- This case highlights the potential for Candida pararugosa to cause serious infections.
- Further research is needed to fully understand the clinical manifestations and pathogenic potential of this yeast.
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