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Visual stimulation quenches global alpha range activity in awake primate V4: a case study.

Thomas Deneux1,2, Timothée Masquelier3,4, Maria A Bermudez1

  • 1Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, Marseille, France.

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|July 7, 2017
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Summary

Sensory stimulation alters brain activity structure, reducing large-scale alpha-range activity and correlations. These changes occur rapidly with low stimulus contrast, indicating a switch in neural processing.

Keywords:
V4awake monkeycorrelationongoing activityoptical imagingvoltage-sensitive dyes

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Sensory stimulation impacts cortical activity levels and structure.
  • Changes in neural activity patterns due to stimulation are not fully understood.
  • Previous studies noted reduced intertrial variability but lacked detailed characterization.

Purpose of the Study:

  • To investigate the spatiotemporal characteristics of visually evoked and spontaneous neuronal activity in V4 of the macaque cortex.
  • To differentiate the structural changes in neuronal activity between spontaneous and stimulated states.
  • To analyze the effect of stimulus contrast on activity dynamics and correlation patterns.

Main Methods:

  • Utilized optical imaging with voltage-sensitive dyes in awake macaque V4.
  • Recorded and analyzed both spontaneous and visually evoked neuronal activity.
  • Quantified large-scale activity, pairwise correlations, and spatial correlation patterns.

Main Results:

  • Sensory stimulation led to a reduction in large-scale activity within the alpha frequency range (5-12.5 Hz).
  • Pairwise neuronal correlations decreased during sensory inflow compared to spontaneous activity.
  • Spatial correlation patterns during visual stimulation were more similar to each other than to patterns without stimulation.
  • Observed changes in activity dynamics saturated at low stimulus contrasts, unlike mean evoked responses.

Conclusions:

  • Sensory input significantly alters the structure of cortical activity, not just its overall level.
  • A distinct shift in neural dynamics occurs with sensory inflow, characterized by reduced alpha activity and correlations.
  • The rapid saturation of these changes suggests a switch-like mechanism in sensory processing at low contrasts.