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Lamisil, a potent alternative antifungal drug for otomycosis

A Zarei Mahmoudabadi1,2, Z Seifi3, M Gharaghani1

  • 1Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Current Medical Mycology
|July 7, 2017
PubMed
Abstract

Insights

Terbinafine (Lamisil) and clotrimazole demonstrated potent in vitro activity against common otomycosis pathogens, including Aspergillus and Candida species. All tested organisms were sensitive to terbinafine, suggesting its potential as a novel treatment for fungal ear infections.

Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Otomycosis is a fungal infection affecting the ear canal, commonly caused by Aspergillus and Candida species.
  • Established antifungal agents like clotrimazole, miconazole, and nystatin are used, but resistance can occur.
  • Lamisil (Terbinafine) is an allylamine antifungal with known efficacy against various fungal infections.

Purpose of the Study:

  • To evaluate the in vitro antifungal activity of Terbinafine (Lamisil) against clinical and environmental isolates of otomycosis pathogens.
  • To compare the efficacy of Terbinafine with established antifungals: clotrimazole, miconazole, and nystatin.

Main Methods:

  • Disk diffusion method was used to assess the susceptibility of 15 clinical and 8 environmental fungal isolates (Aspergillus and Candida species).
  • In vitro activity of Terbinafine, clotrimazole, miconazole, and nystatin was tested against these isolates.
  • Statistical analysis was performed to compare the effects of the antifungals on different isolates.

Main Results:

  • All tested fungal isolates, including Aspergillus and Candida species, were sensitive to clotrimazole and Terbinafine.
  • Nystatin showed resistance in 17.4% of isolates, and miconazole in 4.4%.
  • Terbinafine demonstrated high susceptibility across all tested organisms (P<0.04), with no significant difference in efficacy between environmental and pathogenic isolates.

Conclusions:

  • Terbinafine exhibits significant in vitro activity against the primary causative agents of otomycosis.
  • This study suggests a potential new therapeutic approach using Lamisil (Terbinafine) for treating otomycosis.
  • Clotrimazole also showed broad-spectrum efficacy against the tested fungal isolates.
Keywords:
Aspergillus speciesCandida speciesLamisilOtomycosis

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