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Ascorbic acid antagonizes the behavioural effects of LSD in cats
The Journal of Pharmacy and Pharmacology
|December 1, 1985
Summary
Ascorbic acid pretreatment antagonized behavioral effects of LSD and apomorphine in cats, but not 5-methoxy-N,N-dimethyltryptamine. This suggests these effects involve dopamine and serotonin receptors, with ascorbic acid modulating LSD
Area of Science:
- Neuropharmacology
- Behavioral Neuroscience
Background:
- Lysergic acid diethylamide (LSD) and apomorphine are known to affect neurotransmitter systems.
- Ascorbic acid (vitamin C) has been investigated for its potential modulatory roles in neurological processes.
Purpose of the Study:
- To investigate the antagonistic effects of ascorbic acid on the behavioral outcomes of LSD and apomorphine administration in feline models.
- To explore the involvement of serotonin (5-HT) and dopamine receptors in the observed behavioral changes.
Main Methods:
- Cats were pretreated with ascorbic acid (500 mg kg-1 i.p.).
- Subsequent administration of lysergic acid diethylamide (LSD), apomorphine, and 5-methoxy-N,N-dimethyltryptamine.
- Observation and analysis of induced behavioral changes.
Main Results:
- Ascorbic acid pretreatment significantly antagonized the behavioral effects induced by LSD and apomorphine.
- The behavioral effects of 5-methoxy-N,N-dimethyltryptamine were not antagonized by ascorbic acid.
- Data suggest a role for both 5-HT and dopamine receptors in the observed behaviors.
Conclusions:
- Ascorbic acid's antagonism suggests its interaction with dopamine receptor pathways.
- The findings support a dual action of LSD at both dopamine and serotonin receptors.
- Ascorbic acid appears to modulate the action of LSD specifically at dopamine receptors.