Related Experiment Video
Updated: Feb 27, 2026
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Infantile hemangiomas with minimal or arrested growth associated with soft tissue hypertrophy: a case series of 10
S Planas-Ciudad1, E Roé Crespo1, I Sánchez-Carpintero2
1Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Background:
Infantile hemangiomas with minimal or arrested growth (IH-MAGs) are characterized by a proliferative component of <25% of its surface area. The co-occurrence of IH-MAGs and soft tissue anomalies is rare, and case series of this association are lacking.
Objective:
We present 10 cases of IH-MAGs associated with soft tissue hypertrophy and describe their clinical features.
Methods:
We reviewed all infantile hemangiomas with minimal or arrested growth seen between 2009 and 2016 in the dermatology clinic department at Hospital Santa Creu i Sant Pau, Barcelona. To collect more patients, we also requested cases from the Hemangioma Investigator Group and members of the Spanish Society of Vascular Anomalies.
Results:
Ten patients had IH-MAGs associated with soft tissue hypertrophy; seven involving the arm and three involving the leg. All displayed a segmental pattern, a doughy and puffy texture and prominent surface veins. No significant asymmetries in limbs and no other visceral anomalies were observed at follow-up (range 15 months to 7 years). One patient reported coldness in the limb with infantile hemangioma, but RMI-angiography did not disclose a vascular malformation underneath the lesion. Ulceration was observed in three patients. The proliferative component in all IH-MAGs had faded at 1-year follow-up, while soft tissue hypertrophy and prominent vessels remained unchanged.
Conclusions:
In this first case series of IH-MAGS associated with soft tissue hypertrophy, soft tissue hypertrophy was not progressive and remained unchanged over time, unlike the proliferative component of classic infantile hemangioma. The origin of the prominent vessels and the higher ulceration risk are unknown; however, these findings are probably related to a minor disruption of local vessels not detected in imaging tests.
