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Induction and Analysis of Epithelial to Mesenchymal Transition
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MRTFs- master regulators of EMT.

Ákos Gasparics1,2, Attila Sebe1,3

  • 1Semmelweis University, Department of Pathophysiology, Budapest, Hungary.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|July 7, 2017
PubMed
Summary

Myocardin-related transcription factors (MRTFs) are crucial for cell plasticity, driving myofibroblast differentiation. This review explores their role in development, fibrosis, cancer, and epithelial-mesenchymal transitions (EMTs).

Keywords:
EMTMRTFplasticity

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

Background:

  • Myocardin-related transcription factors (MRTFs) are increasingly recognized for their role in cellular plasticity.
  • Phenotypic plasticity underlies processes like myofibroblast differentiation, fibrosis, and cancer progression.
  • Epithelial-mesenchymal transition (EMT) is a key cellular process involving cell rearrangement and altered gene expression.

Purpose of the Study:

  • To review the function of MRTFs during development, fibrosis, and cancer.
  • To elucidate the role of MRTFs in epithelial-mesenchymal transitions (EMTs).
  • To highlight MRTFs as key mediators of phenotypic plasticity.

Main Methods:

  • Literature review of existing research on MRTFs and EMT.
  • Analysis of signaling pathways and gene expression regulated by MRTFs.
  • Integration of evidence implicating MRTFs in various biological processes.

Main Results:

  • MRTFs mediate the conversion of various cell types into myofibroblasts.
  • MRTFs play a significant role in EMT, a process crucial for development, fibrosis, and cancer.
  • MRTFs regulate key signaling pathways and transcription factors involved in EMT.

Conclusions:

  • MRTFs are central regulators of epithelial-mesenchymal transitions (EMTs).
  • Understanding MRTF function is critical for comprehending development, fibrosis, and cancer.
  • MRTFs represent a key target for therapeutic interventions in diseases involving aberrant EMT.