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Psychiatric comorbidity in Wilson's disease
Gioia Mura1, Paula C Zimbrean2, Luigi Demelia1
1a Department of Medical Sciences and Public Health , University of Cagliari , Cagliari , Italy.
International Review of Psychiatry (Abingdon, England)
|July 7, 2017
Summary
Wilson's disease, a genetic disorder of copper accumulation, frequently causes psychiatric symptoms like mood disorders. Early diagnosis and multidisciplinary care are vital for managing these symptoms and improving patient quality of life.
Area of Science:
- Neurology
- Genetics
- Psychiatry
Background:
- Wilson's disease (WD) is an inherited disorder of copper metabolism.
- Copper accumulation primarily affects the liver and brain, leading to significant health issues.
- Psychiatric disturbances are a notable and challenging aspect of WD diagnosis and treatment.
Purpose of the Study:
- To review the prevalence and impact of psychiatric disorders in Wilson's disease.
- To evaluate the efficacy of current treatments on psychiatric outcomes in WD patients.
- To highlight the importance of a comprehensive approach to managing WD.
Main Methods:
- A systematic literature search was conducted across PubMed/Medline, Scopus, and Google Scholar.
- Included studies published between 1985 and 2016 focusing on psychiatric disorders in WD.
- Analyzed findings from 92 articles, including observational studies, case-control studies, and case reports.
Main Results:
- Psychiatric disorders are common in Wilson's disease patients.
- Mood disorders show a high prevalence among affected individuals.
- Psychiatric symptoms significantly worsen quality of life and psychosocial outcomes.
Conclusions:
- Wilson's disease frequently presents with psychiatric manifestations, impacting patient well-being.
- Effective WD therapies improve life expectancy, emphasizing treatment adherence.
- A multidisciplinary approach involving hepatologic, neurologic, and psychiatric expertise is crucial for optimal patient care and education.
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