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Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death
T Takatani-Nakase1, M Katayama, C Matsui
1School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan. nakase@mukogawa-u.ac.jp.
Molecular Biosystems
|July 7, 2017
Abstract:
Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H2S donor micelle releases H2S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.
