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Updated: Feb 27, 2026
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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[Diabetic nephropathy and cardiovascular risk]
Luigi Rossi1, Loreto Gesualdo2
1Divisione di Nefrologia, Ospedale Generale Regionale Miulli, Acquaviva delle Fonti, Bari, Italy.
Summary
Diabetic nephropathy (DN) presents complex challenges in diagnosis and treatment, despite its commonality. Recent literature highlights evolving understanding of DN progression, differentiation from other kidney diseases, and novel therapeutic strategies for improved patient outcomes.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Diabetic nephropathy (DN) is a significant complication of Diabetes Mellitus (DM).
- It is the leading cause of end-stage renal disease in Western populations.
- Cardiovascular mortality is notably high in patients with DN.
Purpose of the Study:
- To review recent literature on Diabetic Nephropathy (DN).
- To explore epidemiological trends, disease progression, diagnostic challenges, and therapeutic advancements.
- To emphasize the need for improved understanding and management strategies for DN.
Main Methods:
- Literature review of recent publications on Diabetic Nephropathy.
- Analysis of epidemiological data, disease natural history, and diagnostic criteria.
- Evaluation of current and emerging therapeutic interventions for DN.
Main Results:
- DN incidence and prevalence vary, with evolving understanding of its natural progression, including non-proteinuric forms.
- Distinguishing DN from other nephropathies in diabetic patients remains a clinical challenge.
- Recent therapies show promise for nephroprotection in DN patients.
Conclusions:
- Diabetic Nephropathy (DN) is a serious, widespread disease with persistent knowledge gaps.
- Current management strategies require refinement to address the complexities of DN.
- Further research is crucial to alter the unfavorable prognosis of DN.
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