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[Cardio-Pulmonary-Renal interactions].

Sara Samoni1,2, Faeq Husain-Syed1,3, Silvia De Rosa1,4

  • 1International Renal Research Institute Vicenza, Ospedale San Bortolo, Vicenza, Italy.

Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia
|July 7, 2017
PubMed
Summary
This summary is machine-generated.

Cardio-pulmonary-renal interactions are complex, with organ injuries triggering damaging pathways. Understanding these feedback loops aids early diagnosis and treatment of advanced diseases.

Keywords:
biomarkerscardio-pulmonary-renal interactionsfunctional reserveorgan cross-talk

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Area of Science:

  • Cardiovascular medicine
  • Pulmonary medicine
  • Nephrology
  • Physiology

Background:

  • Significant advancements in understanding cardio-pulmonary-renal feedback mechanisms over the last decade.
  • Organ injury can initiate hemodynamic, neuro-hormonal, and cellular pathways, leading to damage in other organs.
  • Chronic conditions reduce functional reserve, increasing susceptibility to acute injury.

Purpose of the Study:

  • To review the current understanding of interactions between the heart, lungs, and kidneys.
  • To highlight the impact of acute-on-chronic injury in disease progression.
  • To emphasize the role of functional reserve assessment and biomarkers in early diagnosis and treatment.

Main Methods:

  • Literature review of recent research on cardio-pulmonary-renal interactions.
  • Synthesis of current knowledge on inter-organ feedback mechanisms.
  • Analysis of pathways involved in organ crosstalk during injury.

Main Results:

  • Cardio-pulmonary-renal interactions involve complex feedback loops influencing organ health.
  • Recurrent acute injuries on chronic conditions accelerate disease progression.
  • Chronic pathologies predispose organs to acute injury due to decreased functional reserve.

Conclusions:

  • A comprehensive understanding of cardio-pulmonary-renal interactions is crucial for managing complex diseases.
  • Early detection through functional reserve assessment and novel biomarkers is key for timely intervention.
  • This review provides a state-of-the-art summary of these critical inter-organ relationships.