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Glycosylated haemoglobin and coronary atherosclerosis in non-diabetic patients: is it a prognostic factor?

Reza Ajudani1,2, Mohammad Saeid Rezaee-Zavareh1,2, Hamidreza Karimi-Sari1,2

  • 1a Student Research Committee , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Acta Cardiologica
|July 7, 2017
PubMed

Insights

Glycemic control, measured by hemoglobin A1c (HbA1c), can help identify coronary artery atherosclerosis in non-diabetic individuals. This study suggests HbA1c is a valuable diagnostic marker for severe coronary artery disease in this population.

Area of Science:

  • Cardiology
  • Endocrinology
  • Clinical Diagnostics

Background:

  • Long-term glycemic disorders increase cardiovascular risk.
  • Previous studies show inconsistent relationships between HbA1c and coronary artery disease (CAD).
  • This research addresses inconsistencies by examining HbA1c's link to coronary artery atherosclerosis.

Purpose of the Study:

  • To investigate the association between HbA1c levels and coronary artery atherosclerosis in non-diabetic patients.
  • To determine if HbA1c can serve as a diagnostic marker for coronary atherosclerosis severity.

Main Methods:

  • A cross-sectional study involving 411 non-diabetic patients undergoing coronary angiography.
  • Assessment of coronary artery atherosclerosis severity using Gensini score and multi-vessel disease criteria.
  • Analysis of the relationship between pre-angiography HbA1c levels and angiographic findings.

Main Results:

  • HbA1c levels effectively differentiated between patients with and without coronary atherosclerosis (p < .001, cut-off = 5.45%).
  • Specific HbA1c cut-off points identified severe CAD (5.55%) and significant stenosis (5.65%).
  • The study evaluated 411 patients, detailing the prevalence of normal angiograms and varying degrees of CAD.

Conclusions:

  • HbA1c is a significant independent diagnostic factor for severe coronary atherosclerosis in non-diabetic individuals.
  • HbA1c may serve as a valuable biomarker for assessing cardiovascular risk in non-diabetic patients.
  • The findings highlight the importance of monitoring glycemic control even in non-diabetic individuals with suspected CAD.
Abstract

Keywords:
Glycosylated haemoglobincoronary artery diseasenon-diabetic patients

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