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Updated: Feb 27, 2026

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
[Gut microbiota and efficacy of cancer therapies]
Marie Vétizou1, Romain Daillère1, Laurence Zitvogel1
1Gustave Roussy Cancer Campus, 39 rue Camille Desmoulins, 94800 Villejuif, France - Université Paris Saclay, 63 rue Gabriel Péri, 94276 Le Kremlin-Bicêtre, France - Unité INSERM U1015, 114 rue Edouard Vaillant, 94800 Villejuif, France.
Abstract:
The gut microbiota is known to affect digestion, protection against pathogens infection, immune system maturation and enteric nervous system development, but others links have also been established with diabetes, obesity, autism and cancer. Lately, bacterial species from the gut have been involved in tumor immunosurveillance. Natural or mediated by treatment such as chemotherapy or immunotherapy, anti-tumoral immune responses seem to rely on gut microbiota. The bacteria involved and their mechanisms of action are different according to the treatment of interest. Nevertheless, modulation of gut microbiota represents a great potential with the development of onco-micro-biotics to optimize the response to cancer therapies.
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