Ulcerative Pyoderma Gangrenosum and Leukocytoclastic Vasculitis in a Hypothyroid Woman: A Case Report

Skin ulcers, especially of the lower extremities, encompass a myriad of causes that a clinician must analyze. Case Re- port. A 45-year-old hypothyroid woman presented with a 6-year history of recurrent widespread eruptions of rashes and ulcers on her skin. She was diagnosed to have pyoderma gangrenosum and leukocytoclastic vasculitis. She was successfully managed with a novel combination of azathioprine and methotrexate.

Pyoderma gangrenosum is an unusual wounding disease that makes the diagnosis and manage- ment challenging. In addition, occurrence of these 2 distinct entities together and their association with preexisting hypothyroidism is new to the scienti c literature and hence discussed here.