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Cancer Survival Analysis01:21

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Related Experiment Video

Updated: Feb 27, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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Setting Quality Improvement Priorities for Women Receiving Systemic Therapy for Early-Stage Breast Cancer by Using

Katherine A Enright1, Nathan Taback1, Melanie Lynn Powis1

  • 1Katherine A. Enright, Trillium Health Partners-Credit Valley Hospital, Mississauga; Katherine A. Enright, Nathan Taback, Rinku Sutradhar, Maureen E. Trudeau, and Monika K. Krzyzanowska, University of Toronto; Melanie Lynn Powis and Monika K. Krzyzanowska, Princess Margaret Cancer Centre; Alejandro Gonzalez, Lingsong Yun, Rinku Sutradhar, and Monika K. Krzyzanowska, Institute for Clinical Evaluative Sciences; Maureen E. Trudeau, Sunnybrook Odette Cancer Centre, Toronto; and Christopher M. Booth, Queen's University, Kingston, Ontario, Canada.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|July 7, 2017
PubMed
Summary

Prioritizing quality measures (QMs) for early-stage breast cancer (EBC) treatment using variation and patient volume identifies key areas for improvement. This approach enhances systemic therapy quality across healthcare systems.

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Area of Science:

  • Oncology
  • Health Services Research
  • Quality Improvement

Background:

  • Routine evaluation of quality measures (QMs) is crucial for identifying and addressing gaps in cancer care.
  • Targeting QMs with substantial performance variation offers the greatest potential for population-level impact.
  • Systemic therapy quality for early-stage breast cancer (EBC) requires focused improvement strategies.

Purpose of the Study:

  • To develop and apply a novel approach for prioritizing quality measures (QMs) in systemic therapy for EBC.
  • To identify QMs with the highest potential for system-level quality improvement based on interinstitutional variation and patient volume.
  • To inform quality improvement initiatives within cancer care systems.

Main Methods:

  • Utilized data from 28,427 EBC patients diagnosed between 2006-2010 in Ontario, Canada.
  • Linked registry and health care data for comprehensive patient and treatment information.
  • Ranked 15 systemic therapy QMs based on interquartile range of performance variation and patient volume, averaging rankings for priority.

Main Results:

  • Identified 84 institutions treating the EBC cohort.
  • Highlighted three key QMs for potential quality improvement: computerized physician order entry for chemotherapy, emergency room visits/hospitalizations during chemotherapy, and timely chemotherapy receipt.
  • Demonstrated the effectiveness of the ranking system in identifying high-impact areas.

Conclusions:

  • A straightforward ranking system integrating performance variation and patient volume effectively identifies priority areas for quality improvement in cancer care.
  • This methodology provides a population-level perspective for optimizing systemic therapy quality.
  • The approach is adaptable to other healthcare systems utilizing quality measures for driving improvements.