Related Experiment Video

Updated: Feb 27, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Sex-specific mortality differences in heart failure patients with ischemia receiving cardiac resynchronization

Zhonglin Han1, Zheng Chen1, Rongfang Lan1

  • 1Department of Cardiology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China.

Plos One
|July 7, 2017
PubMed

Insights

Women with heart failure show better outcomes after cardiac resynchronization therapy (CRT). Ischemic heart disease plays a key role in these sex-specific differences, suggesting targeted approaches may improve CRT effectiveness.

Area of Science:

  • Cardiology
  • Medical Research
  • Clinical Trials

Background:

  • Sex-specific prognosis differences in heart failure patients undergoing cardiac resynchronization therapy (CRT) have been noted.
  • Clinical factors influencing these sex-based disparities require further investigation.

Purpose of the Study:

  • To conduct a meta-analysis investigating factors contributing to sex-specific outcomes in patients receiving CRT.
  • To elucidate the role of ischemic heart disease in observed sex differences.

Main Methods:

  • A comprehensive meta-analysis of studies published between January 1980 and September 2016.
  • Inclusion criteria involved patients receiving CRT with a follow-up exceeding six months.
  • Databases searched included Medline (PubMed) and Embase.

Main Results:

  • Analysis of 58 studies with 33,445 patients (23.08% women) revealed significant benefits for females.
  • Women experienced a 33% reduction in all-cause mortality (HR 0.67) and a 42% reduction in heart failure hospitalization (HR 0.58) compared to men.
  • Stratified analysis indicated that ischemic causes were a significant factor in sex-specific differences in all-cause mortality.

Conclusions:

  • Women demonstrate a reduced risk of mortality and heart failure hospitalization post-CRT.
  • Optimal outcomes in females, particularly those with ischemic heart disease, suggest ischemia is a key factor in sex-related CRT differences.
  • Further research is needed to identify additional mechanisms and indications for sex-specific CRT outcomes.
Abstract

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