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Updated: Feb 27, 2026

Measurement of Force-Sensitive Protein Dynamics in Living Cells Using a Combination of Fluorescent Techniques
Published on: November 2, 2018
Capturing the Dynamics of a Spring-Loaded Protein
Joshua A Mitchell1, Megan L O'Mara1
1Research School of Chemistry (RSC), The Australian National University, Canberra, ACT 2601, Australia.
Abstract:
Skp and other holdase chaperones bind unfolded bacterial outer membrane proteins, preventing premature folding until they insert into the membrane. In this issue of Structure, Holdbrook et al. (2017) use a combination of NMR, SAXS, ensemble optimization, and MD simulations to show that the Skp chaperone samples a much wider range of conformations than suggested by its structure alone.
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