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Risk factors of metabolic bone disease of prematurity

Supamit Ukarapong1, Sunil Kumar Batlahally Venkatarayappa2, Cristina Navarrete3

  • 1Pediatric Endocrinology, University of Miami, Miller School of Medicine, Miami, FL, USA.

Early Human Development
|July 7, 2017
PubMed

Insights

Cholestasis is a significant risk factor for metabolic bone disease of prematurity (MBD) in premature infants. This finding highlights the need for further research into the causal relationship between cholestasis and MBD.

Area of Science:

  • Neonatology
  • Pediatric Gastroenterology
  • Pediatric Endocrinology

Background:

  • Metabolic bone disease of prematurity (MBD) is a common complication in extremely preterm infants.
  • Identifying risk factors is crucial for timely intervention and improved outcomes.

Purpose of the Study:

  • To identify factors associated with an increased risk of developing metabolic bone disease of prematurity (MBD).

Main Methods:

  • Retrospective case-control study of infants born <30 weeks gestation and <1000g birth weight.
  • MBD defined by serum alkaline phosphatase >500 U/L and radiographic changes.
  • Data collected on comorbidities, parenteral nutrition, dexamethasone, and diuretic use.

Main Results:

  • Forty of 76 infants had MBD; median birth weight was lower in the MBD group (560g vs. 765g).
  • Cholestasis showed the highest association with MBD (OR 16.6), followed by seizures (OR 5.2) and prolonged diuretic use (OR 2.6).
  • Cholestasis remained a significant risk factor after multiple regression analysis (OR 9.6).

Conclusions:

  • Cholestasis is a significant risk factor for MBD in premature infants.
  • Further research is warranted to establish a causal relationship between cholestasis and MBD.
Abstract

Keywords:
BonePreterm infantRisk factor and comorbidities

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