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Updated: Feb 27, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Neurotoxicity of fragrance compounds: A review
Adi Pinkas1, Cinara Ludvig Gonçalves1, Michael Aschner1
1Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300, Morris Park Avenue, Forchheimer Building, Room 209, Bronx, NY 10461, United States.
Abstract:
Fragrance compounds are chemicals belonging to one of several families, which are used frequently and globally in cosmetics, household products, foods and beverages. A complete list of such compounds is rarely found on the ingredients-list of such products, as "fragrance mixtures" are defined as "trade secrets" and thus protected by law. While some information regarding the general toxicity of some of these compounds is available, their neurotoxicity is known to a lesser extent. Here, we discuss the prevalence and neurotoxicity of fragrance compounds belonging to the three most common groups: phthalates, synthetic musks and chemical sensitizers.
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