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Different expression patterns of Lin28 and Lin28b in mouse molar development
Ning Dong1, Yan Liu1, Tiantian Zhang1
1Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, 98 XiWu Road, Xi'an, Shaanxi, 710004, China.
Archives of Oral Biology
|July 7, 2017
Summary
Lin28 is crucial for mammalian tooth development, aiding ameloblast and odontoblast differentiation. Lin28b appears to have a distinct role in early tooth germ formation.
Area of Science:
- Developmental biology
- Molecular biology
- Oral biology
Background:
- RNA-binding proteins Lin28 and Lin28b are vital in development and microRNA biosynthesis.
- Their specific functions in mammalian tooth development are not well understood.
Purpose of the Study:
- To investigate the spatiotemporal expression and roles of Lin28 and Lin28b during mouse tooth development.
Main Methods:
- Immunohistochemistry and western blot analysis were used.
- Examined expression from embryonic day E11.5 to postnatal day P21 in mouse molars.
Main Results:
- Lin28 and Lin28b were initially found in dental epithelium.
- Lin28 showed consistent expression in ameloblasts and odontoblasts throughout development.
- Lin28b expression decreased and disappeared after birth.
Conclusions:
- Lin28 is spatiotemporally expressed in tooth germ, suggesting a role in differentiation, matrix secretion, and mineralization.
- Lin28b may have a distinct function in early tooth germ formation.
