Related Experiment Video
Updated: Feb 27, 2026
10:36
Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
15.1K
Noncoding RNAs in the Vascular System Response to Oxidative Stress
Paola Fuschi1, Biagina Maimone1, Carlo Gaetano2
11 Molecular Cardiology Laboratory, IRCCS-Policlinico San Donato, Milan, Italy.
Antioxidants & Redox Signaling
|July 8, 2017
Summary
Non-coding RNAs (ncRNAs) regulate vascular cell function and redox homeostasis. These molecules are key players in oxidative stress responses and hold diagnostic and therapeutic potential for vascular diseases.
Area of Science:
- Vascular biology and molecular medicine.
- Cellular redox homeostasis.
- Non-coding RNA regulation.
Background:
- Redox homeostasis is critical for vascular cell function; its disruption contributes to vascular diseases.
- Mammalian cells require precise gene expression modulation to respond to redox cues.
- Non-protein-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in cellular processes, including vascular responses to oxidative stress.
Purpose of the Study:
- To review the role of ncRNAs in vascular redox homeostasis.
- To highlight ncRNAs regulated by oxidative stress and those modulating reactive oxygen species.
- To discuss the diagnostic and therapeutic potential of ncRNAs in vascular diseases.
Main Methods:
- Literature review focusing on microRNAs and long ncRNAs (lncRNAs).
- Analysis of ncRNA regulation by oxidative stress.
- Examination of ncRNA involvement in vascular pathophysiology.
Main Results:
- ncRNAs, including microRNAs and lncRNAs, are integral to the vascular system's response to oxidative stress.
- Specific ncRNAs are regulated by oxidative stress and influence reactive oxygen species production and scavenging.
- These ncRNAs play significant roles in vascular diseases such as hypoxia, ischemia, inflammation, diabetes, and atherosclerosis.
Conclusions:
- ncRNAs are crucial regulators of vascular redox homeostasis.
- ncRNAs represent promising diagnostic biomarkers and therapeutic targets for vascular diseases.
- Further research into ncRNAs will advance our understanding and treatment of redox-related vascular pathologies.
Related Concept Videos
01:20Vascular Resistance
11.9K
Vascular resistance is a critical concept in understanding blood flow dynamics in the circulatory system. It refers to the resistance that blood encounters as it flows through the blood vessels. This resistance is a key factor in determining blood pressure and cardiac workload.
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...
11.9K
01:24Regulation of Angiogenesis and Blood Supply
3.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.8K
02:39lncRNA - Long Non-coding RNAs
10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
01:31Regulation of the Unfolded Protein Response
3.1K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
3.1K
01:27Regulation of the Cardiovascular System
4.5K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
4.5K
01:30Inflammatory Response I: Vascular and Cellular
17.4K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
17.4K