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Expression of Notch signaling pathway during osteoarthritis in the temporomandibular joint

Lingli Lan1, Yangmei Jiang1, Weina Zhang2

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Journal of Cranio-Maxillo-Facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
|July 8, 2017
PubMed
Abstract

Insights

Notch signaling is activated in temporomandibular joint osteoarthritis (TMJOA). Expression of Notch molecules like Notch1, Jagged1, and Hes5 increases over time in TMJOA cartilage.

Area of Science:

  • Biomedical research
  • Molecular biology
  • Orthopedics

Background:

  • Temporomandibular joint osteoarthritis (TMJOA) is a degenerative joint disease.
  • The role of Notch signaling in TMJOA pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the expression of Notch pathway molecules in TMJOA.
  • To elucidate the potential mechanisms and roles of Notch signaling in TMJOA initiation and progression.

Main Methods:

  • A mouse model of TMJOA was established via discectomy.
  • Histological analysis using a modified Mankin scoring system evaluated cartilage damage.
  • Immunohistochemistry and RT-PCR were employed to assess Notch marker expression (Notch1, Jagged1, Hes1, Hes5).

Main Results:

  • Notch1, Jagged1, and Hes5 expression significantly increased over time in the TMJOA group.
  • Hes1 expression initially decreased then upregulated in the TMJOA group.
  • Control groups showed no significant changes in Notch marker expression.

Conclusions:

  • Notch signaling pathway is activated during TMJOA.
  • Osteoarthritis cartilage exhibits significantly higher expression of Notch molecules.
  • These findings highlight Notch signaling as a potential therapeutic target for TMJOA.
Keywords:
CartilageDiscectomyNotch signaling pathwayOsteoarthritis (OA)Temporomandibular joint (TMJ)

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