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Related Experiment Video

Updated: Feb 27, 2026

Development of a Gaze-Contingent Display Framework Designed for Perceptual and Oculomotor Research with Simulated Central Vision Loss
07:12

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Acquired unilateral scotoma.

Amir H Marvasti1, Kevin C Chen1, Henry A Ferreyra1

  • 1Department of Ophthalmology, Shiley Eye Institute, University of California San Diego, La Jolla, California, USA.

Survey of Ophthalmology
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

A patient presented with a blind spot in his vision. Imaging revealed changes consistent with acute zonal occult outer retinopathy (AZOOR), a rare outer retinal disease.

Keywords:
acute zonal occult outer retinopathyautofluorescenceenlarged blind spotoptical coherence tomographyvisual field

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Visual Electrophysiology

Background:

  • Acute zonal occult outer retinopathy (AZOOR) is an idiopathic inflammatory condition affecting the outer retina.
  • It typically presents with unilateral visual field defects and characteristic fundus autofluorescence findings.

Observation:

  • A 54-year-old male reported a temporal blind spot in his left eye with normal visual acuity.
  • Humphrey visual field testing showed an enlarged blind spot.
  • Fundus examination revealed peripapillary pigmentary changes.

Findings:

  • Fundus autofluorescence demonstrated a distinct peripapillary region with both hyperautofluorescence and hypoautofluorescence.
  • Spectral-domain optical coherence tomography (SD-OCT) confirmed outer retinal degenerative changes.
  • The clinical presentation and imaging findings led to a diagnosis of AZOOR.

Implications:

  • This case highlights the importance of multimodal imaging in diagnosing AZOOR.
  • Understanding AZOOR's imaging features aids in differentiating it from other outer retinal pathologies.
  • Early diagnosis and monitoring are crucial for managing patients with AZOOR.