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The relationship between S-adenosylhomocysteine and coronary artery lesions: A case control study

Xinrui Huang1, Xin Lv2, Hui Song1

  • 1Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 8, 2017
PubMed

Insights

Plasma S-adenosylhomocysteine (SAH) levels are higher in patients with coronary artery disease (CAD). Elevated SAH is independently associated with coronary artery lesions, suggesting it may be a novel biomarker for cardiovascular disease.

Area of Science:

  • Cardiology
  • Biochemistry

Background:

  • Homocysteine's role in coronary artery disease (CAD) is debated.
  • Emerging evidence suggests S-adenosylhomocysteine (SAH) may be more relevant to cardiovascular disease (CVD).

Purpose of the Study:

  • To investigate the association between plasma SAH levels and coronary artery lesions.
  • To evaluate SAH as a potential biomarker for early CVD identification.

Main Methods:

  • 160 patients with suspected CAD underwent coronary angiography.
  • Plasma concentrations of SAH and S-adenosylmethionine (SAM) were measured.
  • Association between coronary artery lesions and SAH was analyzed.

Main Results:

  • CAD patients exhibited significantly higher plasma SAH levels compared to atherosclerosis patients.
  • Plasma SAH concentrations were independently associated with coronary artery lesions.
  • SAM/SAH ratio was higher in the atherosclerosis group; SAM, Hcy, folate, and B12 levels were similar.

Conclusions:

  • Plasma SAH is independently associated with coronary artery lesions in patients undergoing coronary angiography.
  • SAH may serve as a novel biomarker for the early clinical detection of cardiovascular disease.

Keywords:
Coronary artery lesionsFolateHomocysteineS-adenosylhomocysteineS-adenosylmethionine

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