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Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
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Extracellular Vesicles in Lung Disease.

Hiroshi Kubo1

  • 1Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine, Sendai, Japan.

Chest
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) are implicated in lung disease development and progression. These vesicles, including exosomes and ectosomes, show potential as lung disease biomarkers and therapeutic targets.

Keywords:
COPDectosomesexosomesextracellular vesiclesidiopathic pulmonary fibrosis

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Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Biochemistry

Background:

  • Extracellular vesicles (EVs), encompassing exosomes, ectosomes, and apoptotic bodies, are increasingly recognized for their role in lung disease pathogenesis.
  • EVs are released by cells under activation or apoptosis, particularly during inflammation, with their quantity and type varying with disease state.

Purpose of the Study:

  • To review the role of extracellular vesicles (EVs) in lung disease.
  • To highlight the potential of EVs as biomarkers and therapeutic targets in pulmonary medicine.

Main Methods:

  • Literature review of studies investigating extracellular vesicles in lung diseases.
  • Analysis of EV biogenesis, content, and function in the context of pulmonary pathophysiology.

Main Results:

  • Extracellular vesicles (EVs) are released by activated or apoptotic cells and differ based on pathophysiological status.
  • EVs contain proteins, nucleic acids (mRNA, microRNA), and DNA, capable of transferring these molecules to recipient cells.
  • Circulating EVs influence lung microenvironment and targeted cells, suggesting therapeutic potential.

Conclusions:

  • Extracellular vesicles (EVs) represent promising novel biomarkers for diagnosing and monitoring various lung diseases.
  • The unique molecular transfer capabilities of EVs position them as potential drug delivery systems and therapeutic targets for lung diseases.