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Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000-2014

Joseph F Hayes1, Louise Marston2, Kate Walters2

  • 1Joseph F. Hayes, MSc, MB, ChB, Division of Psychiatry, University College London, London; Louise Marston, PhD; Kate Walters, PhD, Department of Primary Care and Population Health, University College London, London; Michael B. King, PhD, David P. J. Osborn, PhD, Division of Psychiatry, University College London, London, UK joseph.hayes@ucl.ac.uk.

The British Journal of Psychiatry : the Journal of Mental Science
|July 8, 2017
PubMed

Insights

The mortality gap for individuals with bipolar disorder and schizophrenia is widening compared to the general population. This study tracked excess mortality trends in these patient groups over time.

Area of Science:

  • Psychiatry
  • Public Health
  • Epidemiology

Background:

  • Bipolar disorder and schizophrenia are linked to higher mortality rates than the general population.
  • International efforts aim to reduce this excess mortality.
  • Understanding mortality trends is crucial for public health interventions.

Purpose of the Study:

  • To investigate changes in the mortality gap between individuals with bipolar disorder or schizophrenia and the general population.
  • To assess trends in excess mortality over a 15-year period.

Main Methods:

  • A large-scale, nationally representative cohort study utilizing electronic health records from 2000 to 2014.
  • Comparison of all-cause mortality between patients diagnosed with bipolar disorder or schizophrenia and the general population.
  • Statistical analysis using adjusted hazard ratios (HR) to quantify mortality risk.

Main Results:

  • Individuals with bipolar disorder and schizophrenia exhibited significantly elevated all-cause mortality (HRs 1.79 and 2.08, respectively).
  • The mortality gap for bipolar disorder widened significantly from 2006-2014 (HR increased by 0.14/year).
  • The mortality gap for schizophrenia showed a rapid widening after 2010 (HR increased by 0.34/year).

Conclusions:

  • The disparity in mortality rates between individuals with bipolar disorder or schizophrenia and the general population is increasing.
  • Findings highlight an urgent need for targeted interventions to address widening health inequities.
  • Continued monitoring of mortality trends is essential for effective public health strategies.

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