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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold.

Boyeong Kang¹, Woojin Yang¹, Sebok Lee¹

¹Department of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology, 123 Cheomdan-gwagiro, Buk-gu, Gwangju, 61005, South Korea.

Scientific Reports

|July 8, 2017

Summary

Researchers created pigment-helix conjugates to precisely control energy transfer, mimicking natural photosynthesis. This breakthrough offers highly efficient energy transfer, paving the way for artificial photosynthetic systems.

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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

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Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Area of Science:

Biochemistry
Materials Science
Photochemistry

Background:

Natural photosynthesis efficiently channels energy through precise spatial arrangement of pigments.
Helices serve as scaffolds to maintain pigment organization in photosynthetic systems.

Purpose of the Study:

To develop porphyrin-peptoid conjugates (PPCs) for precise control over donor-acceptor energy transfer efficiency.
To mimic the design principles of natural photosynthetic proteins for artificial systems.

Main Methods:

Construction of five donor-acceptor molecular dyads using zinc porphyrin and free base porphyrin.
Measurement of energy transfer efficiency using static fluorescence emission in dichloromethane (CH2Cl2) and femtosecond transient absorption in toluene.

Main Results:

PPCs demonstrated highly efficient energy transfer, with efficiencies ranging from 92% to 96% (fluorescence) and 96.3% to 97.6% (transient absorption).
Energy transfer efficiency was modulated by controlling the relative distance and orientation of donor-acceptor pigment pairs.

Conclusions:

The developed PPCs achieve remarkable precision and tunability in energy transfer, comparable to natural photosynthesis.
Mimicking natural photosynthetic protein design principles is a viable strategy for creating efficient artificial energy transfer systems.