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Direct protein quantification in complex sample solutions by surface-engineered nanorod probes.

Stefan Schrittwieser1, Beatriz Pelaz2,3, Wolfgang J Parak2,4

  • 1Molecular Diagnostics, AIT Austrian Institute of Technology, Vienna, Austria. Stefan.Schrittwieser@ait.ac.at.

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Summary

This study introduces a simple nanorod biosensor for detecting breast cancer biomarker sHER2 in serum and saliva. This method simplifies molecular diagnostics for point-of-care applications.

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Area of Science:

  • Molecular Diagnostics
  • Nanotechnology
  • Biomarker Detection

Background:

  • Detecting biomarkers in complex samples is crucial for molecular diagnostics.
  • Point-of-care applications require simple, equipment-free, and rapid detection methods.

Purpose of the Study:

  • To develop a nanorod-based homogeneous biosensing approach for direct detection of the breast cancer biomarker sHER2.
  • To enable point-of-care diagnostics with simplified sample preparation and operation.

Main Methods:

  • Utilized nanorod surface engineering and homogeneous assay design for specific sHER2 detection.
  • Employed a sandwich assay format on nanorods for enhanced detection sensitivity.
  • Investigated the role of protein corona formation for in-situ reference measurements.

Main Results:

  • Achieved specific detection of sHER2 directly from serum and saliva samples.
  • Demonstrated a limit of detection of 110 pM in diluted saliva and 470 pM in diluted serum.
  • Showcased the method's robustness despite protein corona formation.

Conclusions:

  • The nanorod-based biosensor offers a simplified and effective method for protein biomarker quantification.
  • This approach is highly suitable for point-of-care settings with limited resources.
  • Opens applications for direct protein biomarker detection in clinical diagnostics.