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Updated: Feb 27, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Molecular genetics complexity impeding research progress in breast and ovarian cancers
Ishita Gupta1, Ikram Burney2, Mansour S Al-Moundhri2
1Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Sultanate of Oman.
This study reviews genomic and proteomic alterations in breast and ovarian cancers. Researchers identified potential biomarkers and pathways for improved targeted therapies and patient outcomes.
Area of Science:
- Oncology
- Genomics
- Proteomics
Background:
- Breast and ovarian cancers are heterogeneous and lethal, with limited targeted therapy success, especially in triple-negative breast cancer and epithelial ovarian cancer.
- Understanding cancer pathogenesis is crucial for improving prevention, prognosis, and management of these diseases.
- Oman faces significant rates of breast (25%) and ovarian (4.5%) cancers.
Purpose of the Study:
- To provide a comprehensive review of genomics and proteomics alterations in cancer pathogenesis.
- To identify novel pathways involved in breast and ovarian cancer development.
- To explore potential biomarkers for targeted therapy development.
Main Methods:
- Literature review of global research on cancer genomics and proteomics.
- Laboratory analysis using microarray and chromatin immunoprecipitation (ChIP).
Main Results:
- Candidate genes were found to be differentially expressed (up- or downregulated) in breast cancer cases.
- ChIP analysis indicated that E2F5 transcription factor regulates candidate genes in ovarian cancer tissue.
- Potential biological markers for targeted therapies were identified.
Conclusions:
- Genomic and proteomic alterations are key to understanding breast and ovarian cancer pathogenesis.
- Identified genes and pathways offer promise for developing novel targeted therapies.
- Further validation of candidate genes as biomarkers is ongoing to improve cancer treatment.
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