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Mast cell, pro-inflammatory and anti-inflammatory: Jekyll and Hyde, the story continues

P Conti1, Al Caraffa2, S K Kritas3

  • 1Immunology Division, Postgraduate Medical School, University of Chieti, Chieti, Italy.

Journal of Biological Regulators and Homeostatic Agents
|July 8, 2017
PubMed

Insights

This study compares interleukin-10 (IL-10) and interleukin-37 (IL-37), two anti-inflammatory cytokines. Both IL-10 and IL-37 effectively inhibit mast cell inflammatory cytokines in various conditions.

Area of Science:

  • Immunology
  • Cytokine Biology

Background:

  • Mast cells (MCs) are key immune cells involved in inflammation, allergy, and cancer.
  • MCs release pro-inflammatory mediators and are regulated by cytokines like IL-10.
  • Interleukin-1 family members exhibit diverse roles in both inflammation and anti-inflammation.

Discussion:

  • Interleukin-10 (IL-10) is a pleiotropic cytokine that suppresses Th1 inflammatory responses and inhibits cytokines like TNF, IFN-γ, IL-1, and IL-6.
  • Interleukin-37 (IL-37), a newer family member, binds the IL-18 receptor α chain and inhibits inflammatory mediators including TNF, IL-1, IL-6, IL-33, and nitric oxide.
  • Both IL-10 and IL-37 demonstrate inhibitory effects on mast cell-derived inflammatory cytokines.

Key Insights:

  • IL-37 shares functional similarities with IL-10 in suppressing mast cell-driven inflammation.
  • The study provides a comparative analysis of these two critical anti-inflammatory cytokines.
  • Both cytokines show potential therapeutic relevance in inflammatory disorders and cancer.

Outlook:

  • Further research is warranted to elucidate the precise mechanisms and therapeutic applications of IL-37 compared to IL-10.
  • Investigating the synergistic or differential effects of IL-10 and IL-37 could reveal novel treatment strategies.
  • Understanding these cytokine interactions is crucial for managing inflammatory conditions and cancer.

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