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Recent advances on biodegradable polymeric carrier-based mucosal immunization: an overview.
Lovedeep Kaur1, Ankush Sharma1, Awesh Kumar Yadav2
1a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
Artificial Cells, Nanomedicine, and Biotechnology
|July 8, 2017
Summary
Mucosal vaccines delivered via nasal routes using mucoadhesive polymeric nanoparticles offer enhanced immunity. This review covers recent advancements and patents in polymeric carrier systems for mucosal immunization.
Area of Science:
- Immunology
- Nanotechnology
- Polymer Science
Background:
- Mucosal surfaces are crucial for immunity against microbial infections.
- Mucosal vaccine delivery induces both humoral and cellular immune responses.
- The nasal route is advantageous for vaccine administration due to ease and enhanced immune response.
Purpose of the Study:
- To review recent developments in mucosal vaccine delivery systems.
- To highlight the use of mucoadhesive polymeric carriers for nasal immunization.
- To summarize recent patents related to mucosal immunization strategies.
Main Methods:
- Review of scientific literature on mucosal vaccine delivery.
- Analysis of studies utilizing natural and synthetic polymers for nanoparticle carriers.
- Examination of patents concerning polymeric carriers for mucosal immunization.
Main Results:
- Polymeric nanoparticles serve as effective carriers for mucosal vaccine delivery.
- Mucoadhesive properties enhance antigen retention and immune response at mucosal sites.
- Recent patents demonstrate growing interest in polymeric carriers for mucosal vaccines.
Conclusions:
- Mucoadhesive polymeric carriers represent a promising strategy for effective mucosal vaccine development.
- Nasal delivery systems are advancing the field of mucosal immunization.
- Further research and development in this area are supported by recent patent approvals.
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