Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

10.8K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.8K
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

51
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
51
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.1K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Iron dyshomeostasis and enhanced myelination in the prefrontal cortex and ventral basal ganglia of a DJ-1 knockout model of early-onset Parkinson's disease.

Neurobiology of disease·2026
Same author

Electrochemical Oxidation of Water Through Conducting Polymer for Hydroxyl Radical Generation at Ultra-Low Voltage.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Genomic mapping reveals cisplatin disruption of protein phosphorylation signalling genome-wide.

Metallomics : integrated biometal science·2026
Same author

Multi-Dimensional Insights Into the Surface and Interfaces of Battery Materials by Time-of-Flight Secondary Ion Mass Spectrometry.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Molecular unraveling of Li<sup>+</sup>-solvent interaction reversal and its impact on low-temperature desolvation for weakly solvated electrolytes.

Science bulletin·2026
Same author

In-Situ Metabolic Profiling of Single Living Cells by Liquid Secondary Ion Mass Spectrometry.

Analytical chemistry·2026

Related Experiment Video

Updated: Feb 27, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.5K

Multi-Targeted Anticancer Agents.

Wei Zheng1, Yao Zhao1, Qun Luo1,2

  • 1Beijing National Laboratory for Molecular Sciences; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; National Centre for Mass Spectrometry in Beijing; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.

Current Topics in Medicinal Chemistry
|July 8, 2017
PubMed
Summary
This summary is machine-generated.

Novel anticancer drugs are crucial due to rising cancer rates. This research explores single-molecule, multi-target agents combining multiple pharmacophores to improve efficacy and combat drug resistance in cancer therapy.

Keywords:
Anticancer agentsBCR-ABLCytotoxic anticancer drug.Drug developmentMulti-targetingPrecision medicine

More Related Videos

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.9K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Related Experiment Videos

Last Updated: Feb 27, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

4.5K
Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

12.9K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Drug Development

Background:

  • Cancer remains a leading cause of morbidity and mortality worldwide.
  • Chemotherapy is a cornerstone of cancer treatment, but targeted therapies are gaining prominence.
  • Cancer's complex, multi-gene nature necessitates innovative therapeutic strategies.

Purpose of the Study:

  • To review the recent advancements in "single molecule, multi-target" anticancer agents.
  • To highlight the potential of combining multiple pharmacophores within a single molecule.
  • To discuss both organic and metal-based multi-target anticancer agents.

Main Methods:

  • Literature review of "single molecule, multi-target" anticancer agents.
  • Categorization of agents into organic and metal-based complexes.
  • Discussion of specific metal complexes (platinum, ruthenium, iridium, rhodium).

Main Results:

  • Development of novel anticancer agents that act on multiple targets simultaneously.
  • Demonstration of enhanced efficacy and reduced drug resistance with multi-target agents.
  • Exploration of diverse chemical structures, including organic compounds and metal complexes.

Conclusions:

  • "Single molecule, multi-target" agents represent a promising future direction for anticancer drug development.
  • These agents have the potential to overcome limitations of traditional chemotherapy and targeted therapies.
  • Further development of these agents could significantly benefit clinical cancer therapy and patient outcomes.