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Updated: Feb 27, 2026

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

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Published on: November 16, 2018

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Bioglass® 45S5-based composites for bone tissue engineering and functional applications.

M Rizwan1,2, M Hamdi3, W J Basirun4

  • 1Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.

Journal of Biomedical Materials Research. Part A
|July 8, 2017
PubMed
Summary

Bioglass® 45S5 composites enhance bone and soft tissue regeneration by combining Bioglass® with metals, ceramics, and polymers. These advanced materials offer improved mechanical properties for tissue engineering scaffolds.

Keywords:
Bioglass® 45S5angiogenicbioactivitycompositessoft tissue

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Materials Science

Background:

  • Bioglass® 45S5 (BG) exhibits excellent bone and soft tissue bonding but is limited by brittleness for load-bearing scaffolds.
  • BG-based composites integrate BG's bioactivity with other materials' structural properties.
  • BG possesses angiogenic and antibacterial properties, expanding its therapeutic potential.

Purpose of the Study:

  • To review BG-based composites for hard and soft tissue engineering applications.
  • To discuss BG composites with metals, ceramics, and polymers.
  • To analyze the influence of production techniques on scaffold bioactivity and mechanical behavior.

Main Methods:

  • Literature review of BG-based composites.
  • Analysis of composite applications in bone and nerve regeneration.
  • Discussion of BG composites in soft tissue engineering.

Main Results:

  • BG composites show promise for bone scaffolds, nerve regeneration, and soft tissue engineering.
  • Composite production methods significantly impact bioactivity and mechanical performance.
  • BG-based composites demonstrate good in vitro and in vivo biocompatibility and biodegradation.

Conclusions:

  • BG-based composites are suitable scaffold materials for both hard and soft tissues.
  • Material selection and processing techniques are critical for optimizing scaffold performance.
  • Further research is needed to fully realize the potential of BG composites in regenerative medicine.