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The Telomeric Complex and Metabolic Disease.

Henriette Kirchner1, Fozia Shaheen2, Hannes Kalscheuer3

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Telomere attrition is linked to aging and metabolic dysfunction. This review explores damaging events contributing to telomere shortening in metabolic diseases.

Keywords:
diabetesleucocyte telomere lengthmetabolic diseasesobesity telomere shortening

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Area of Science:

  • Genetics and Molecular Biology
  • Metabolic Health
  • Aging Research

Background:

  • Telomere attrition is implicated in mammalian aging.
  • Disturbed nutrient sensing is associated with metabolic dysfunctions.
  • The role of telomere shortening in chronic diseases is debated.

Purpose of the Study:

  • To review damaging events contributing to telomere shortening.
  • To explore the association between telomere shortening and metabolic diseases.
  • To discuss whether telomere shortening is a cause or consequence of metabolic disease.

Main Methods:

  • Literature review of scientific articles.
  • Analysis of studies on telomere biology.
  • Synthesis of research on nutrient sensing and metabolic health.

Main Results:

  • Identified various damaging events linked to telomere attrition.
  • Established connections between telomere shortening and metabolic dysfunction.
  • Highlighted the complex relationship between telomere length and chronic disease.

Conclusions:

  • Telomere attrition is a significant factor in aging and metabolic health.
  • Understanding the causes of telomere shortening is crucial for metabolic disease research.
  • Further investigation is needed to clarify the causal role of telomeres in metabolic disorders.