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The Association between Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk in Children

Anna Di Sessa1, Giuseppina Rosaria Umano2, Emanuele Miraglia Del Giudice3

  • 1Department of Woman, Child and General and Specialized Surgery, University of Studies of Campania "Luigi Vanvitelli", 80138 Napoli, Italy. anna.disessa@libero.it.

Children (Basel, Switzerland)
|July 8, 2017
PubMed

Insights

Childhood obesity is increasing Non-Alcoholic Fatty Liver Disease (NAFLD) globally. Pediatric NAFLD is linked to cardiovascular disease (CVD) risk, including early heart abnormalities.

Area of Science:

  • Pediatric Cardiology
  • Hepatology
  • Public Health

Background:

  • Non-Alcoholic Fatty Liver Disease (NAFLD) is the leading cause of pediatric chronic liver disease globally.
  • Childhood obesity rates have significantly increased over recent decades, contributing to NAFLD prevalence.
  • Emerging evidence suggests a strong association between pediatric NAFLD and cardiovascular disease (CVD).

Purpose of the Study:

  • To review current knowledge on the relationship between pediatric NAFLD and cardiovascular risk.
  • To clarify the role of NAFLD as a potential cardiovascular risk factor in children.
  • To highlight early subclinical cardiovascular abnormalities associated with pediatric NAFLD.

Main Methods:

  • Literature review of existing studies on pediatric NAFLD and cardiovascular outcomes.
  • Analysis of data linking NAFLD to cardiovascular events and subclinical cardiac changes in children.
  • Synthesis of current understanding of NAFLD's impact on pediatric cardiovascular health.

Main Results:

  • Pediatric NAFLD is increasingly recognized as an independent risk factor for cardiovascular events.
  • NAFLD in children is associated with early, subclinical abnormalities in myocardial structure and function.
  • The link between NAFLD and cardiovascular risk is evident even in early childhood.

Conclusions:

  • Pediatric NAFLD represents a significant and emerging cardiovascular risk factor.
  • Early identification and management of NAFLD in children are crucial for mitigating future cardiovascular complications.
  • Further research is warranted to fully elucidate the mechanisms linking NAFLD to pediatric cardiovascular disease.

Keywords:
Non-Alcoholic Fatty Liver Diseaseabnormalitiesatherosclerosiscardiaccardiovasculardiseasesrisk

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