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Updated: Feb 27, 2026

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Response to Intravenous Glucose-Tolerance Test and Risk of Cancer: A Long-Term Prospective Cohort Study
R S Falk1, S Tretli2, J E Paulsen3
1Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Men with rapid glucose elimination after an intravenous glucose-tolerance test (IVGTT) showed a higher cancer risk over 40 years. This suggests early glucose metabolism may influence cancer development.
Area of Science:
- Metabolic Health
- Oncology
- Epidemiology
Background:
- Impaired glucose regulation is linked to cancer risk.
- Previous studies focused on oral glucose-tolerance tests.
- The association with intravenous glucose-tolerance tests (IVGTT) remains unexplored.
Purpose of the Study:
- To investigate the association between IVGTT response and cancer risk in healthy middle-aged men.
- To determine if rapid glucose elimination predicts future cancer incidence.
Main Methods:
- A cohort of 945 healthy men (40-59 years) underwent IVGTT.
- Glucose levels were measured for 1 hour post-injection.
- Follow-up for cancer incidence lasted 40 years, analyzed with Cox models.
Main Results:
- Men with lower 10-minute glucose levels post-IVGTT had higher cancer incidence (IRR: 1.5).
- This association persisted after adjusting for confounders (HR: 1.6) and excluding early follow-up (HR: 1.5).
Conclusions:
- Rapid early-phase glucose elimination following an IVGTT is associated with elevated cancer risk.
- First-phase glucose metabolism may play a role in cancer development.
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