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Gut peptides in lactation.

N Holst, T G Jenssen, P G Burhol

    British Journal of Obstetrics and Gynaecology
    |February 1, 1986
    PubMed
    Summary
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    This study found that prolactin (PRL) and pancreatic polypeptide (PP) levels increase during breastfeeding. Simultaneously, somatostatin (SRIH) levels significantly decrease, suggesting a role for these hormones in human lactation.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Reproductive Biology

    Background:

    • Human breastfeeding involves complex hormonal regulation.
    • Gastrointestinal regulatory peptides may play a role in lactation.

    Purpose of the Study:

    • To investigate the role of gastrointestinal regulatory peptides in human breastfeeding.
    • To measure circulating levels of hormones like prolactin (PRL) and somatostatin (SRIH) during lactation.

    Main Methods:

    • Blood samples were collected from nine nursing women 27-40 days postpartum.
    • Circulating levels of PRL, vasoactive intestinal polypeptide (VIP), somatostatin (SRIH), cholecystokinin (CCK), pancreatic polypeptide (PP), insulin, motilin, and blood glucose were measured.
    • Hormone levels were analyzed during the suckling period.

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    Main Results:

    • Serum prolactin (PRL) levels significantly increased during the last 20 minutes of suckling (P < 0.05).
    • Plasma somatostatin (SRIH) levels significantly decreased during suckling (P < 0.05 at 20 min, P < 0.01 at 30 min).
    • A strong inverse correlation was found between PRL and SRIH levels during breastfeeding (r = -0.996, P < 0.001).
    • Pancreatic polypeptide (PP) levels also significantly increased during nursing (P < 0.01).
    • No significant changes were observed in VIP, CCK, insulin, or motilin levels.

    Conclusions:

    • Prolactin (PRL) and somatostatin (SRIH) exhibit significant reciprocal changes during human breastfeeding.
    • Pancreatic polypeptide (PP) also increases during lactation, suggesting its involvement.
    • These findings highlight the potential roles of PRL, SRIH, and PP in the physiological regulation of human breastfeeding.