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Updated: Feb 27, 2026

Reconstitution of Msp1 Extraction Activity with Fully Purified Components
Published on: August 10, 2021
The mitochondrial unfolded protein response: Signaling from the powerhouse
Mohammed A Qureshi1, Cole M Haynes2, Mark W Pellegrino3
1From the Department of Biology, University of Texas Arlington, Arlington, Texas 76019 and.
Abstract:
Mitochondria are multifaceted and indispensable organelles required for cell performance. Accordingly, dysfunction to mitochondria can result in cellular decline and possibly the onset of disease. Cells use a variety of means to recover mitochondria and restore homeostasis, including the activation of retrograde pathways such as the mitochondrial unfolded protein response (UPRmt). In this Minireview, we will discuss how cells adapt to mitochondrial stress through UPRmt regulation. Furthermore, we will explore the current repertoire of biological functions that are associated with this essential stress-response pathway.
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