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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Phase Contrast and Differential Interference Contrast Microscopy01:26

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Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
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Related Experiment Video

Updated: Feb 27, 2026

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
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Propagation-based Phase-Contrast X-ray Imaging at a Compact Light Source.

Regine Gradl1,2,3, Martin Dierolf4,5, Lorenz Hehn4,6

  • 1Chair of Biomedical Physics, Department of Physics, Technical University of Munich, James-Franck-Str. 1, 85748, Garching, Germany. regine.gradl@tum.de.

Scientific Reports
|July 9, 2017
PubMed
Summary
This summary is machine-generated.

This study shows that X-ray phase-contrast imaging works well with a compact light source. This technique can be used for live small animal bio-imaging research with fast exposures.

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Area of Science:

  • Medical Imaging
  • Biophysics
  • X-ray Optics

Background:

  • X-ray phase-contrast imaging offers enhanced sensitivity for soft tissues.
  • Compact light sources are emerging as alternatives to synchrotrons for X-ray applications.

Purpose of the Study:

  • To assess the feasibility of propagation-based X-ray phase-contrast imaging using a compact light source.
  • To evaluate the performance of this setup for phantom and small animal imaging.

Main Methods:

  • Utilized the Munich Compact Light Source, providing a quasi-monochromatic and partially coherent beam.
  • Performed propagation-based X-ray phase-contrast imaging on known phantoms and a mouse model.
  • Applied quantitative phase-retrieval algorithms.

Main Results:

  • Observed significant edge-enhancement in phantom images.
  • Successfully retrieved quantitative phase information from phantoms.
  • Acquired high-contrast images of mouse lungs and airways with short exposure times.

Conclusions:

  • Propagation-based X-ray phase-contrast imaging is applicable with compact light sources.
  • This technique shows potential for live small animal bio-imaging and functional studies.
  • Compact sources offer a viable, high-flux alternative for advanced X-ray imaging.