Maturation of circulatory system in three mammalian models of human development

The review surveys the literature on maturation of vasoconstrictor and vasodilator functions in cerebral, renal and intestinal circulations of three non-primate models of human development. An ovine model has been refined for use at both fetal and neonatal stages of development. Important variables controlling regional circulations in the lamb fetus at term include arterial O2 content and pCO2 (brain), angiotensin-II (kidney) and norepinephrine (small intestine). Blood flow autoregulation to decreasing perfusion pressure has been inferred for the renal circulation of the neonate. A canine model has been employed in the postnatal period, usually later than the first week after birth. Important variables controlling regional circulations in the young puppy include arterial pO2 and pCO2 (brain) and epinephrine and angiotensin-II (kidney). Blood flow autoregulation to decreasing pressure has been demonstrated in the cerebral circulation at birth and in the renal circulation at one week thereafter. The intestinal circulation has not been studied with respect to blood flow control. A porcine model has been examined from birth through at least two months of postnatal life. Important variables controlling regional circulations in swine at birth include adrenergic nerve stimulation, arterial pCO2 (brain), angiotensin-II (kidney) and norepinephrine (kidney and small intestine). Blood flow autoregulation to decreasing perfusion pressure has been demonstrated in the brain by the fourth day, in the kidney by the end of the second week and in the small intestine by the end of the first month after birth. The advantage of each model for further investigation of functional maturation of regional circulatory control is summarized.